methotrexate drug pathway methotrexate pharmacokinetics pathway 2012-04-27T01:46:47Z MTX pharmacokinetics pathway PW:0000931 The pathway of processing - absorption, distribution, metabolism or elimination - of methotrexate (MTX), a folate analogue used in the treatment of cancers and autoimmune diseases. Genetic variations can result in changes in the availability of the drug and It is believed that variability in MTX pharmacokinetics is linked to genetic variations in transporter proteins. pathway vpetri