methotrexate drug pathway methotrexate pharmacodynamics pathway 2012-04-27T02:16:39Z MTX pharmacodynamics pathway PW:0000932 SMP:00432 The pathway of methotrexate-target interaction and of the biochemical or physiological responses to drug. The impact of MTX on cancer and rheumatoid arthritis is thought to arise through distinct mechanisms and pharmacodynamics pathways. Genetic variations can cause differences in the response of the organism to the drug. pathway vpetri