infectious disease pathway Bordetella pertussis infection pathway 2012-07-11T03:37:54Z KEGG:05133 PW:0001043 The Gram-negative Bordetella pertusis is the causative agent of pertussis or whooping cough. One of its main virulence factors, pertussis toxin blocks the interaction of Galphai subunit of heterotrimeric G protein with its partner receptors. This results in unrestrained adenylyl cyclase activity and subsequent increased concentration of cAMP which affects normal intracellular signaling. VPetri pathway pertussis pathway