part_of translation pathway ribosome biogenesis pathway 2012-07-25T03:15:38Z PW:0001066 The pathway of ribosome biogenesis starts with the transcription of rRNA precursors, and involves the co-transciptional events of pre-rRNA processing and the assembly of pre-ribosomal particles. The maturation of pre-40S and pre-60S particles follows independent routes. Once in the cytoplasm, additional steps yield the mature, translation-competent ribosome. Alterations in the pathway result in specific phenotypes collectively known as ribosomopathies. pathway ribosome biogenesis vpetri