hypoxia inducible factor pathway altered oxygen homeostasis pathway altered transcription factor mediated signaling pathway altered hypoxia inducible factor pathway 2012-10-04T11:04:37Z A hypoxia inducible pathway that deviates from what its normal course should be. Mutations in the von Hippel-Lindau (Vhl), the E3 ubiquitin ligase which targets Hif alpha for degradation under normoxic conditions, lead to a constitutively active pathway regardless the levels of oxygen. Mutations in Vhl and a number of other genes have been implicated in renal cancers. PW:0001102 pathway vpetri altered transcription pathway via transcription factor mediated signaling