everolimus drug pathway 2012-10-19T13:54:12Z PW:0001126 The pharmacokinetics and pharmacodynamics pathway of everolimus, an inhibitor of mTOR pathway used in the treatment of several types of tumors, including renal cell carcinoma. Hypoxia inducible factor (HIF) pathway is constitutively active in the disease; mTOR regulates the translation of HIF-alpha gene. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug. pathway vpetri antineoplastic drug pathway immunosuppressant drug pathway