chemical compound signaling pathway cannabinoid signaling pathway 2012-11-13T09:02:41Z Cannabinoids are a class of rather diverse chemical compounds of which some, like endocannabinoids, are naturally produced by the body in humans and other animals, while others are found in plants or are synthesized. Signaling is mediated by the cannabinoid receptors that are G-protein-coupled (GPCR) receptors. The endogenous cannabinoids are lipids and the signaling route is referred to as retrograde as it travels 'backwards' from the postsynaptic to the presynaptic cell. PW:0001163 pathway vpetri