fibroblast growth factor signaling pathway endocrine fibroblast growth factor signaling pathway 2013-01-29T11:20:53Z PW:0001175 The endocrine fibroblast growth factors (FGF) also known as hormone-like belong to the 15/19/21/23 phylogenetic subfamily, also referred to as FGF19 subfamily. They have low affinity for the fibroblast growth factor receptors (FGFR) and rely on the Klotho family members to bind the receptors under physiological conditions. In particular, FGF23 signaling via Klotho, also known as the FGF23/Klotho axis plays a central role in vitamin D metabolism and renal phosphate homeostasis. Deregulation of the pathway has been associated with several conditions. endocrine FGF signaling pathway fibroblast growth factor subfamily 19 signaling pathway pathway vpetri