signaling pathway kinase mediated signaling pathway 2013-03-12T10:32:24Z Kinases are essential components of biological pathways. Phosphorylaton by protein kinases and dephosphorylation by protein phosphatases exert major regulatory roles. In addition, they can also initiate intracellular signaling cascades. Kinases represent a significant fraction of eukaryotic genes and prominent amongst them are the serine/threonine kinases. PW:0001193 pathway vpetri