pemetrexed drug pathway pemetrexed pharmacodynamics pathway 2013-04-05T09:27:10Z Alimta pharmacodynamics pathway PW:0001214 The pathway of pemetrexed-target interactions and of the biochemical or physiological responses to drug. The drug is an antifolate that targets thymidylate synthase and other enzymes of the folate cycle and folate mediated one-carbon transfer reactions and is used in the treatment of several cancers. Genetic variations can cause differences in the response of the organism to the drug. pathway vpetri