pralatrexate drug pathway pralatrexate pharmacodynamics pathway 2013-04-05T09:39:53Z Folotyn pharmacodynamics pathway PW:0001218 The pathway of pralatrexed-target interactions and of the biochemical or physiological responses to drug. The drug is an antifolate that targets dihydrofolate reductase (DHFR) and is used in the treatment of some cancers. Genetic variations can cause differences in the response of the organism to the drug. pathway vpetri