ACE inhibitor drug pathway 2013-05-03T11:54:00Z PW:0001228 The pharmacokinetics and pharmacodynamics of drugs that target the angiotensin converting enzyme ACE. In the renin-angiotensin cascade, several bioactive peptides are derived from the precursor angiotensinogen. ACE converts angiotensin I to the potent angiotensin II. The various ACE inhibitors are grouped based on their molecular structure, the dicarboxylate-containing agents represent the largest group. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug. VPetri pathway renin-angiotensin system drug pathway