part_of RNA polymerase II transcription pathway RNA polymerase II transcription initiation pathway 2013-05-13T09:10:45Z PW:0001274 RNA Polymerase II Transcription Initiation RNA polymerase II and a set of general and specific transcription factors assemble as a large pre-initiation complex which undergoes a series of transformations before transcription proceeds. Promoter recognition and subsequent initiation of transcription are dependent upon the presence of these transcription factors. Activators and repressors impact upon transcription at these early stages. pathway transcription initiation at RNA polymerase II promoter vpetri