part_of histone modification pathway 2013-06-03T14:06:55Z PW:0001338 The tails of histone proteins are subject to a wide array of modifications of which methylation and acetylation have been more thoroughly documented. The modified residues are recognized by particular proteins or readers, in turn acting upon their targets. The modifications are rendered reversible by the enzymes that carry out the reaction in the opposite direction, also referred to as erasers. histone modification pathway vpetri chromatin modification pathway S-adenosylmethionine homeostasis pathway