transcription factor mediated signaling pathway transcription pathway via transcription factor mediated signaling peroxisome proliferator-activated receptor signaling pathway 2013-06-05T08:45:28Z PPAR signaling pathway PW:0001355 Peroxisome proliferator-activated receptor signaling is initiated in response to binding several compounds within classes of lipids such as the eicosanoids, leukotrienes and prostagladins, among others. The receptors form heterodimers with the retinoid X receptor, bind to specific DNA elements and regulate the expression of target genes. Deregulation of the pathway has been implicated in several conditions. pathway peroxisome proliferator activated receptor signaling pathway vpetri