pathway pertinent to DNA replication and repair, cell cycle, maintenance of genomic integrity, RNA and protein biosynthesis DNA damage response pathway 2013-06-11T11:03:38Z DDR pathway PW:0001360 The response mechanism/pathways that assure the maintenance of genomic integrity. This involves detection of DNA damage, signaling and amplification of the signal leading to activation of effectors and resulting in repair of damage, cell cycle arrest or, if necessary, cell death. Such response mechanism/pathways may operate collectively with some of their components being shared. pathway vpetri