part_of serine/threonine-specific kinase mediated signaling pathway DNA damage response pathway ATM and Rad3-related (ATR) signaling pathway 2013-06-11T11:25:59Z ATR signaling pathway PW:0001362 The ATM and Rad3-related (ATR) serine/threonine kinase mediated signaling responds to several kinds of DNA damage, of which single-stranded DNA (ssDNA) exerts a key role. ssDNAs are induced by stressed replication forks. ATR acting on its substrates prevents the cell from erroneous mitotic entry, plays a key role in interstrand cross link (ICL) repair pathway and also exerts important regulatory roles in homologous recombination pathway of double-strand break repair. VPetri pathway