chromatin remodeling pathway SWI/SNF family mediated chromatin remodeling pathway 2013-06-25T13:27:31Z PW:0001406 The SWI/SNF (switching defective/sucrose nonfermenting) family of remodelers has initially been purified from Saccharomyces cerevisiae. In mammals, two complexes are comprised of one of two mutually exclusive catalytic ATPase subunits along with a set of conserved core subunits and variant subunits. The SWI/SNF is involved in nucleosome sliding and ejection. Deregulation of pathway is associated with several human cancers. pathway vpetri