chromatin remodeling pathway ISWI family mediated chromatin remodeling pathway 2013-06-25T13:37:13Z PW:0001407 The ISWI (imitation switch) family of remodelers has initially been purified from Drosophila melanogaster. Eukaryotes assemble several ISWI complexes using one or two different catalytic subunits. Many complexes function to promote chromatin assembly and repression of transcription. Overall, the pathway is important for DNA replication and repair along with the regulation of transcription. pathway vpetri