arthritis pathway gout pathway 2013-07-12T11:32:52Z A metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and around the joints, sometimes with formation of uric acid calculi. Elements of the gout pathway potentially contributory to the disease are urate excretion by renal transporters where mutations in these genes can increase the risk of gout, hepatic production of urate, urate crystal formation in joints and initiation of the inflammatory response. PW:0001441 gout disease pathway pathway vpetri