nicotine drug pathway nicotine pharmacodynamics pathway 2013-08-28T13:58:07Z PW:0001450 SMP:00431 The pathway of nicotine-target interaction and of the biochemical or physiological responses to drug. Nicotine is an agonist of the nicotinic acetylcholine receptors and exerts stimulatory roles. It is also responsible for tobacco dependence. Prolonged exposure and high levels of nicotine can have toxic effects. Genetic variations can cause differences in the response of the organism to the drug. pathway vpetri