congenital adrenal hyperplasia pathway lipoid congenital adrenal hyperplasia pathway 2013-10-31T11:04:45Z CLAH pathway LCAH disease pathway Lipoid congenital adrenal hyperplasia, the most severe disorder of steroid hormone biosynthesis, is caused by a defect in the conversion of cholesterol to pregnenolone, the first step in adrenal and gonadal steroidogenesis. All affected individuals are phenotypic females with a severe salt-losing syndrome that is fatal if not treated in early infancy. PW:0001479 SMP:00371 adrenal hyperplasia 1 pathway congenital adrenal hyperplasia pathway congenital lipoid adrenal hyperplasia pathway lipoid CAH pathway lipoid congenital adrenal hyperplasia disease pathway pathway vpetri