metformin drug pathway metformin pharmacokinetics pathway 2013-12-17T09:49:19Z PW:0001489 The pathway of processing - absorption, distribution, metabolism or elimination - of metformin, an anti-diabetic drug used in the treatment of type 2 diabetes mellitus. Metformin is widely distributed in various tissues. Meformin is excreted unchanged and several transporters are involved in its tissue uptake and elimination. Genetic variations can result in changes in the availability of the drug. pathway vpetri