metformin drug pathway metformin pharmacodynamics pathway 2013-12-17T09:49:49Z PW:0001490 The pathway of metformin-target interaction and of the biochemical or physiological responses to drug. Metformin lowers blood glucose levels by promoting the activation of AMPK signaling via molecular mechanisms that are not well understood. Mitochondria is the primary target of metformin which specifically inhibits complex I of the respiratory chain. The resulting change in AMP:ATP ratio can contribute to AMPK activation. Genetic variations can cause differences in the response of the organism to the drug. pathway vpetri