platinum (Pt) containing drug pathway 2014-02-26T10:07:43Z PW:0001507 The pharmacokinetics/pharmacodynamics of platinum (Pt) containing drugs, widely used in the treatment of cancer. These drugs introduce intra- and inter-strand DNA breaks. The DNA lesion and responses it triggers is toxic to tumor cells. However, it can also exert toxic side effects. Three Pt-containing drugs are being used and they vary in their efficacy and toxicity. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug. pathway vpetri antineoplastic drug pathway