homologous recombination pathway of double-strand break repair altered double-strand DNA repair pathway altered homologous recombination pathway of double-strand break repair 2014-07-29T15:45:06Z Defective repair pathway(s) of double-strand breaks can lead to chromosomal rearrangements, genomic instability and oncogenic activation. Mutations in several components of the homologous recombination (HR) pathway have been implicated in several conditions in both an autosomal dominant and recessive fashion. PW:0001555 altered HR pathway of double-strand break repair pathway vpetri