musculoskeletal disease pathway very long-chain acyl-CoA dehydrogenase deficiency pathway 2015-02-10T12:37:35Z PW:0001594 SMP:00540 VLCAD deficiency is due to alterations in fatty acid beta oxidation pathway. It is an inherited metabolic disease due to mutations in the ACADVL gene. It appears in infancy or early childhood and is manifested as lack of energy and muscle weakness. VLCAD deficiency pathway pathway vpetri inborn error of lipid metabolism pathway