bisphosphonate drug pathway nitrogenous bisphosphonate drug pathway 2015-02-16T10:25:18Z PW:0001621 The pharmacokinetics and pharmacodynamics pathway of nitrogenous bisphosphate drugs, inhibitors of farnesyl diphosphate synthase. The disruption of geranyl and farnesyl pyrophosphate production affects the cell membrane localization of proteins that depend on this lipid modification for proper placement. They include the members of the small G proteins and the impact on Ras, Rho and Rac G proteins is thought to underlie the effect of drugs. pathway vpetri