alteplase drug pathway 2015-02-26T13:08:24Z PW:0001635 The pharmacokinetics and pharmacodynamics pathway of alteplase - one of several recombinant tissue plasminogen activators. Plasminogen is a key player in the fibrinolytic cascade pathway of blood clots breakdown. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug. pathway vpetri thrombolytic drug pathway