alteplase drug pathway alteplase pharmacodynamics pathway 2015-02-26T13:16:32Z PW:0001637 SMP:00280 The pathway of alteplase-target interaction and of the biochemical or physiological responses to drug. Alteplase is one of several recombinant tissue plasminogen activators. Alteplase is used for treatment of myocardial infarction and ischemic stroke, among others. Genetic variations can cause differences in the response of the organism to the drug. pathway vpetri