tolmetin drug pathway tolmetin pharmacodynamics pathway 2015-06-12T10:47:22Z PW:0001750 SMP:00704 The pathway of tolmetin-target interaction and of the biochemical or physiological responses to drug. Tolmetin is thought to inhibit cyclooxygenases and thus block prostaglandin synthesis. Genetic variations can cause differences in the response of the organism to the drug. pathway vpetri