RNA processing pathway radical SAM enzyme mediated RNA processing pathway 2015-07-29T10:12:30Z PW:0001766 RNA molecules such as ribosomal and transfer RNA, rRNA and tRNA respectively, undergo many modifications to achieve functionality. Among the many modifications, there are those introduced by iron-sulfur (Fe/S) cluster-containing enzymes. Most have radical S-adenosylmethionine (SAM) domains that use SAM to produce 5-adenosyl radical; the intermediate allows them to mediate a vast range of chemical transformations. pathway vpetri radical SAM enzyme mediated metabolic pathway