metolazone drug pathway 2015-09-17T14:03:11Z PW:0001925 The pharmacokinetics and pharmacodynamics pathway of metolazone - a blocker of sodium -chloride symporter in the distal convoluted tubule of the nephron. The drug is used for the treatment of hypertension and congestive heart failure. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug. pathway vpetri diuretic drug pathway