DNA replication pathway eukaryotic DNA replication pathway 2015-09-24T12:48:55Z DNA Replication Nuclear eukaryotic DNA replication takes place in the context of the cell cycle during the S-phase. The fast and accurate replication of DNA requires the presence and the coordinated function of a complex of proteins known as the replisome. The exact composition of the replisome in higher organisms still has to be fully determined. Mitochondria contain their own DNA. Human mtDNA is a small, circular molecule that resides in the matrix and, depending on cell type, can exist as a few to several thousands copies. mtDNA has its own replicative machinery. PW:0001954 cell cycle DNA replication pathway vpetri