part_of stress response pathway mitochondria homeostasis pathway mitochondrial unfolded protein response pathway 2015-09-25T09:07:21Z A stress response pathway to mitochondrial DNA depletion or accumulation of misfolded protein in the matrix or intermembrane space. Mitochondrial-to-nucleus signaling results in the increased expression of genes important for mitochondrial protein homeostasis. UPRmt can promote increased lifespan but the mechanisms are not well understood. Mitochondrial dysfunction contributes to normal aging, but mild distress can extend lifespan by almost 50% in organisms ranging from yeast to worms, flies and mice. PW:0001975 UPRmt pathway mitochondrial unfolded protein response pathway vpetri