renin-angiotensin system drug pathway irbesartan drug pathway 2015-09-28T15:08:55Z PW:0001982 The pharmacokinetics and pharmacodynamics pathway of irbesartan, an angiotensin II receptor type 1 antagonist used in the treatment of hypertension. Irbesartan is one of several angiotensin II receptor antagonists. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug. pathway vpetri