imipramine drug pathway imipramine pharmacodynamics pathway 2015-09-28T15:28:05Z PW:0001987 SMP:00422 The pathway of imipramine-target interaction and of the biochemical or physiological responses to drug. The drug is used in the treatment of major depression and its effect results from inhibition of serotonin and norepinephrine neurotransmitter reuptake. Genetic variations can cause differences in the response of the organism to the drug. pathway vpetri