hydrochlorothiazide drug pathway hydrochlorothiazide pharmacodynamics pathway 2015-10-01T15:25:40Z PW:0002005 SMP:00100 The pathway of hydrochlorothiazide-target interaction and of the biochemical or physiological responses to drug. The drug reduces sodium reabsorption in the distal convoluted tubule of kidney nephron. Genetic variations can cause differences in the response of the organism to the drug. pathway vpetri