furosemide drug pathway furosemide pharmacodynamics pathway 2015-10-02T13:13:35Z PW:0002016 SMP:00115 The pathway of furosemide-target interaction and of the biochemical or physiological responses to drug. The drug blocks the luminal sodium-potassium-chloride symporter in the thick ascending limb of the loop of Henle. Furosemide is used in the treatment of hypertension and edema. Genetic variations can cause differences in the response of the organism to the drug. pathway vpetri