disulfiram drug pathway disulfiram pharmacodynamics pathway 2015-10-13T14:17:28Z PW:0002065 SMP:00429 The pathway of disulfiram-target interaction and of the biochemical or physiological responses to drug. The drug inhibits the enzyme acetaldehyde dehydrogenase and also appears to prevent the breakdown of dopamine. Disulfiram is used in the treatment of chronic alcoholism and also cocaine dependence. Genetic variations can cause differences in the response of the organism to the drug. pathway vpetri