desipramine drug pathway 2015-10-21T09:52:53Z PW:0002088 The pharmacokinetics and pharmacodynamics pathway of desipramine, an antidepressant used in the treatment of depression and attention deficit disorder. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug. pathway vpetri non-selective monoamine reuptake inhibitor drug pathway