cardiovascular system drug pathway diuretic drug pathway 2015-10-29T11:30:44Z PW:0002121 The pharmacokinetics and pharmacodynamics of drugs that increase water excretion and are used in the treatment of hypertension, heart failure and certain kidney disorders. They are further categorized by type. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug. pathway vpetri