diuretic drug pathway chlorthalidone drug pathway 2015-10-29T11:40:14Z PW:0002122 The pharmacokinetics and pharmacodynamics pathway of chlorothalidone - a blocker of sodium -chloride symporter in the distal convoluted tubule of the nephron. The drug is used for the treatment of hypertension and also as an adjuvant drug for treating edema. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug. pathway vpetri