chlorthalidone drug pathway chlorthalidone pharmacodynamics pathway 2015-10-29T12:29:10Z PW:0002124 SMP:00122 The pathway of chlorthalidone-target interaction and of the biochemical or physiological responses to drug. The drug blocks the sodium-chloride symporter and is used in the treatment of hypertension and as an adjuvant for treating edema. Genetic variations can cause differences in the response of the organism to the drug. pathway vpetri