direct thrombin inhibitor drug pathway 2015-11-02T11:47:17Z PW:0002146 The pharmacokinetics and pharmacodynamics pathway of drugs that reduce or prevent the formation of blood clots by directly inhibiting thrombin. Thrombin is a serine protease involved in coagulation-related reactions. The drugs are further classified depending on how they interact with thrombin. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug. pathway vpetri anticoagulant drug pathway