bumetanide drug pathway bumetanide pharmacodynamics pathway 2015-11-02T15:23:10Z PW:0002155 SMP:00088 The pathway of bumetanide-target interaction and of the biochemical or physiological responses to drug. The drug blocks the luminal sodium-potassium-chloride symporter in the thick ascending limb of the loop of Henle. Bumetanide is used in the treatment of heart failure. Genetic variations can cause differences in the response of the organism to the drug. pathway vpetri