proton pump inhibitor drug pathway esomeprazole drug pathway 2015-11-05T15:16:44Z PW:0002182 The pharmacokinetics and pharmacodynamics pathway of esomeprazole, a proton pump inhibitor. It is administered for the treatment of acid-related disorders. The drug inhibits the hydrogen potassium ATPase in the parietal cells of the stomach. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug. pathway vpetri