antihemorrhagic drug pathway aprotinin drug pathway 2015-11-12T09:49:08Z PW:0002221 The pharmacokinetics and pharmacodynamics pathway of aprotinin, an antifibrinolytic inhibitor of trypsin and other serine proteases, used to reduce bleeding during surgery. Once withdrawn from the market, it has been reintroduced. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug. pathway vpetri