thrombolytic drug pathway reteplase drug pathway 2015-11-20T10:47:08Z PW:0002256 The pharmacokinetics and pharmacodynamics pathway of reteplase - one of several recombinant tissue plasminogen activators. Plasminogen is a key player in the fibrinolytic cascade pathway of blood clots breakdown. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug. pathway vpetri