musculo-skeletal system drug pathway analgesic and/or antipyretic drug pathway indometacin drug pathway 2015-12-02T14:30:20Z PW:0002303 The pharmacokinetics and pharmacodynamics pathway of indometacin, a non-steroidal anti-inflammatory drug that inhibits cyclooxygenase enzymes and is used in the treatment of inflammation and pain and to reduce fever. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug. pathway vpetri